Medicinal plants of the Western ghats as possible inhibitors of oxidationin various biological lipid substrates

Namratha Pai, K. and Vanitha Reddy, P. and Asna Urooj (2016) Medicinal plants of the Western ghats as possible inhibitors of oxidationin various biological lipid substrates. Annals of Phytomedicine, 5 (2). pp. 118-123. ISSN 2393-9885

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Abstract

Medicinal plants are nature’s fighters against several degenerative diseases. The reversepharmacological approach focuses on traditional knowledge on the usage of medicinal plants forvarious diseases and revalidating the effect using modern techniques. The Western ghats of SouthernIndia has sheltered a wide range of medicinal plants. The objective of this research work was toevalu ate the oxidation inhibiting ability of aqueou s extract of fou r medicinal plants from theWestern ghats, namely; Andrographispaniculata (Burm.f.) Wall. ex Nees, Costus speciosus (Koen.)Sm., Canth ium parviflorum Lam.and Abru s p reca torius L. in biological lipid substrates, viz.,cholesterol, low-density lipoprotein and brain homogenate. The IC50 values of the plant extractswere calculated and the correlation between the phytochemicals and the antioxidant effect exhibitedwas stu died. From the resu lts, it was observed that, the inhibition of oxidation by the aqu eousextract of all the four medicinal plants, followed the order cholesterol >LDL> brain homogenate.C. parviflorum exhibited highest antioxidant activity in cholesterol (94.8%) and brain (37.35%)than compared to other medicinal plants. In LDL, the highest antioxidant activity (73.75%) wasexhibited by C. speciosus. The antioxidant activity of CP and CS in the substrates correlated wellwith the polyphenol and flavonoid content of the extracts. T he IC50 values of CS in cholesterol(305 μg, r2 = 0.9972) was the least among all the medicinal plants. The overall protective action inthe substrates was higher in C. parviflorum than other medicinal plants. Thus, the selected medicinalplants can be further explored for its biological activity and utilized as sources of natural antioxidantsand phytochemicals against various oxidative stress related diseases

Item Type:	Article
Subjects:	B Life Science > Food Science and Nutrition
Divisions:	Department of > Food Science and Nutrition
Depositing User:	Manjula P Library Assistant
Date Deposited:	04 Jun 2019 07:20
Last Modified:	30 Jun 2020 10:19
URI:	http://eprints.uni-mysore.ac.in/id/eprint/2343

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