Effects of B-endorphin and its receptor antagonist, naltreoxone on the pubertal ovarian follicular development in rat

Kalid, H. A. and Yajurvedi, H. N. (2013) Effects of B-endorphin and its receptor antagonist, naltreoxone on the pubertal ovarian follicular development in rat. Biochemical And Cellular Archives, 13 (1). p. 169. ISSN 0972-5075

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Abstract

Administration (ip) of b- endorphin 0.5ìg or 1 ìg / 0.1 ml/ rat/ day to pre-pubertal rats from post-natal day 15 to 21 resulted in a significant reduction in , i) gain in body weight, ii) relative weight of the ovary, uterus and Fellopian tubes, iii) mean number of primary, pre-antral and antral follicles and iv) serum levels of estradiol compared to controls. The changes were more drastic in higher dose of b- endorphin treated rats than in lower dose treated rats. In another experiment, administration of naltrexone, an opioid receptor antagonist, 1 ìg or 5 ìg /rat/day from post-natal day 15 to 21 along with 0.5ìg b- endorphin prevented alterations in ovarian follicular development and steroidogenic activity thereby indicating that ovarian alterations were specific actions of b - endorphin. The results for the first time indicate that b- endorphin interferes with ovarian follicular development in mammals.

Item Type:	Article
Uncontrolled Keywords:	B-Endorphin and Estradiol and Naltrexone and Ovary and Stress
Subjects:	B Life Science > Food Science and Nutrition
Divisions:	Department of > Zoology
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	14 Jan 2020 09:46
Last Modified:	14 Jan 2020 09:46
URI:	http://eprints.uni-mysore.ac.in/id/eprint/10769

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