Synthesis of novel indole based scaffolds holding pyrazole ring as anti-inflammatory and antioxidant agents

Sharath, V. and Vijay Kumar, H. and Naik, N. (2013) Synthesis of novel indole based scaffolds holding pyrazole ring as anti-inflammatory and antioxidant agents. Journal of Pharmacy Research, 6 (7). pp. 785-790.

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Abstract

Aim: To synthesize substituted indole based scaffolds having pyrazole ring and evaluate for their anti-inflammatory activity and antioxidant. Method: The structures of newly synthesized compounds were elucidated by spectroscopic methods such as IR, 1 H NMR, 13C NMR, mass, 1 H NMR spectra and elemental analysis. Antioxidant assays like 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2-azino bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS þ) radical ion decolorization assay and lipid peroxidation activity (LPO) were performed. Anti-inflammatory activity was studied using linoleic acid as substrate and lipoxidase enzyme. Results: Among the synthesized analogues compound 7d revealed broad-spectrum of antioxidant activity and on the other hand compound 7c exhibits a promising antiinflammatory activity. Conclusion: The achieved results prove that the distinctive compounds could serve as promising lead candidates and also for acclimatization and investigation to construct more active analogues.

Item Type:	Article
Uncontrolled Keywords:	Antioxidant Activity and Anti-Inflammatory Activity and Chalcones and Indole and Pyrazole
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	07 Jan 2020 05:10
Last Modified:	07 Jan 2020 05:10
URI:	http://eprints.uni-mysore.ac.in/id/eprint/10372

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