Synthesis of novel indole based scaffolds holding pyrazole ring as anti-inflammatory and antioxidant agents

Abstract

Aim

To synthesize substituted indole based scaffolds having pyrazole ring and evaluate for their anti-inflammatory activity and antioxidant.

Method

The structures of newly synthesized compounds were elucidated by spectroscopic methods such as IR, ¹H NMR, ¹³C NMR, mass, ¹H NMR spectra and elemental analysis. Antioxidant assays like 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2-azino bis (3-ethylbenzothiazoline-6-sulfonic acid) (${\text{ABTS}}^{+}$) radical ion decolorization assay and lipid peroxidation activity (LPO) were performed. Anti-inflammatory activity was studied using linoleic acid as substrate and lipoxidase enzyme.

Results

Among the synthesized analogues compound 7d revealed broad-spectrum of antioxidant activity and on the other hand compound 7c exhibits a promising anti-inflammatory activity.

Conclusion

The achieved results prove that the distinctive compounds could serve as promising lead candidates and also for acclimatization and investigation to construct more active analogues.