Expedient synthesis of 1,2,4-triazolin-3-one derivatives as DNA cleavage and antioxidant agents

Taj, T. and Kamble, R. R. and Kattimani, P. P. and Sudha S. Belgur (2013) Expedient synthesis of 1,2,4-triazolin-3-one derivatives as DNA cleavage and antioxidant agents. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 52 (6). pp. 794-801. ISSN 0376-4699

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Abstract

The present study involves the synthesis of fluoren-9-ylidene 5a-e and isoindolin-1,3-dione derivatives 5f-j appended to 1,2,4-triazolin-2-one under solvent and neat conditions. The title compounds have been evaluated for the extent of cell penetration through biological membranes (clogP) and drug score has been calculated and further screened for DNA cleavage and antioxidant activities.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Yuvaraj college > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	12 Nov 2019 09:57
Last Modified:	12 Nov 2019 09:58
URI:	http://eprints.uni-mysore.ac.in/id/eprint/9607

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