Synthesis and biological activity of some pyrimidine derivatives

Mohana, K. N. and Prasanna Kumar, B. N. and Mallesha, L. (2013) Synthesis and biological activity of some pyrimidine derivatives. Drug Invention Today, 5 (3). pp. 216-222. ISSN 0975-7619

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Abstract

Objectives: To synthesize a variety of pyrimidine analogs, 3, 4, 5, 6(a-d), 7(a-d) and their anticonvulsant and antioxidant activity was determined. Methods: Using 5-bromo-2,4-dichloropyrimidine and hydrazine hydrate, new compounds were synthesized. The structures of all the new compounds are established on the basis of FT-IR, 1H NMR and mass spectral data. Anticonvulsant study was done by MES seizure model and rotorod method was employed to determine the neurotoxicity. Antioxidant activity was done by DPPH method. Results: All the compounds were synthesized in good yield. Among the new compounds, 6c and 7c are found to be most potent and showed no neurotoxicity. All the compounds showed DPPH radical scavenging activity, where compounds 7b, 7a and 6b were the best radical scavengers. Conclusions: The results obtained justify the usage of these compounds from their promising anticonvulsant and antioxidant activity. Therefore, the nature of groups is very important for anticonvulsant activity in MES model.

Item Type:	Article
Uncontrolled Keywords:	2, 3, 3 c]pyrimidine, 3 c]pyrimidine 3 amine, 3 methoxybenzaldehyde (5 bromo 2 chloropyrimidin 4 yl)hydrazone, 4 dichlorobenzaldehyde (5 bromo 2 chloropyrimidin 4 yl)hydrazone, 4 dichloropyrimidine, 4 dimethoxybenzaldehyde (5 bromo 2 chloropyrimidin 4 yl)hydrazone, 4]triazolo4, 5 bromo 2, 5 bromo 2 chloro 4 (3, 5 dimethyl 1h pyrazol 1 yl)pyrimidine, 6 diflurobenzaldehyde (5 bromo 2 chloropyrimidin 4 yl)hydrazone, 8 bromo 5 chloro 3 (4 ethylphenyl)1, 8 bromo 5 chloro 3 (4 methoxyphenyl)1, 8 bromo 5 chloro 3 (4 methylphenyl)1, 8 bromo 5 chloro 3 aryl1, 8 bromo 5 chloro 3 methyl1, 8 bromo 5 chloro1, animal experiment, animal model, anticonvulsant activity, antioxidant activity, article, ascorbic acid, controlled study, convulsion, drug potency, drug structure, drug synthesis, hydrazine, infrared spectroscopy, male, mass spectrometry, neurotoxicity, nonhuman, phenytoin, proton nuclear magnetic resonance, pyrimidine derivative, rat, unclassified drug
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	22 Oct 2019 07:22
Last Modified:	22 Oct 2019 07:22
URI:	http://eprints.uni-mysore.ac.in/id/eprint/9119

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