Synthesis and Antimicrobial Studies on New Substituted 1,3,4-Oxadiazole Derivatives Bearing 6-Bromonaphthalene Moiety

Mayekar, Anil and Yathirajan, H. S. and Narayana, B. and Sarojini, B. K. and Kumari, N. (2010) Synthesis and Antimicrobial Studies on New Substituted 1,3,4-Oxadiazole Derivatives Bearing 6-Bromonaphthalene Moiety. International Journal of Chemistry, 2 (1). ISSN 1916-9701

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Abstract

A series of new 1, 3, 4-oxadiazole derivatives having 6-bromonaphthalene moiety are synthesized. 2-[(6-bromo-2-naphthyl) oxy] acetohydrazide was treated with various substituted aromatic acids in presence of POCl3 to give 2-{[(6-bromo-2-naphthyl) oxy] methyl}-5-aryl-1, 3, 4-oxadiazole. Also the hydrazide on treating with CS2/KOH gave 5-{[(6-bromo-2-naphthyl) oxy] methyl}-1, 3, 4-oxadiazole-2 (3H)-thione, which was subjected to Mannich reaction to get a series of Mannich bases and with alkyl/aryl halide to give 2-{[(6-bromo-2-naphthyl) oxy] methyl}-5-[(alkyl/aryl) thio]-1, 3, 4-oxadiazole. The newly synthesized compounds were characterized by analytical and spectral data. Antimicrobial activities of these compounds were carried out and some of them have exhibited good activity.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	14 Oct 2019 05:44
Last Modified:	14 Oct 2019 05:44
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8998

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