Removal of some commonly used protecting groups in peptide syntheses by catalytic transfer hydrogenation with formic acid and 10% palladium on carbon

Channe Gowda, D. (2002) Removal of some commonly used protecting groups in peptide syntheses by catalytic transfer hydrogenation with formic acid and 10% palladium on carbon. Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry, 41B (5). pp. 1064-1067. ISSN 0975-0983

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Abstract

It is shown that HCOOH, a good solvent for most peptides, can be conveniently used as a hydrogen donor for catalytic transfer hydrogenation with less expensive 10% Pd on C when compared to palladium black. The protecting groups that are being successively removed include the Nα-benzyloxycarbonyl, Nɛ-2-chlorobenzyloxycarbonyl, C- terminal benzyl ester, O-benzyl ether of O-benzyltyrosine, serine or threonine, nitro of nitroarginine and Nim-benzyloxymethyl of histidine.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	30 Sep 2019 07:24
Last Modified:	30 Sep 2019 07:24
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8636

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