Kinetics and mechanism of oxidation of L-isoleucine and L-ornithine hydrochloride by sodium N-bromobenzenesulphonamide in perchloric acid medium

Yathirajan, H. S. and Raju, C. R. and Mohana, K. N. and Shashikanth, S. and Nagaraja, P. (2003) Kinetics and mechanism of oxidation of L-isoleucine and L-ornithine hydrochloride by sodium N-bromobenzenesulphonamide in perchloric acid medium. Turkish Journal of Chemistry, 27 (5). pp. 571-580. ISSN 303-6130

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Abstract

Kinetic studies of the oxidation of L-isoleucine (ISL) and L-ornithine hydrochloride (ORH) by sodium N-bromobenzenesulphonamide (bromamine-B or BAB) were studied in aqueous perchloric acid medium. The rate shows first-order dependence on both [BAB](0) and [amino acid](0) and inverse first-order dependence on [H+] for ISL and first-order dependence on [H+] for ORE. The rate of reaction decreased with decreases in the dielectric constant of the medium. The addition of benzenesulphonamide (BSA), which is one of the reaction products, had no significant effect on the reaction rate. The rate remained unchanged with the variation in the ionic strength of the medium for ISL, whereas the rate decreased with increases in the ionic strength of the medium for ORR Isovaleronitrile and 3-(methylamino)propionitrile were identified as the products. Thermodynamic parameters were computed by studying the reactions at different temperatures (298-316 K). The rate laws derived are in excellent agreement with the experimental results. Plausible mechanisms are suggested.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	25 Sep 2019 04:22
Last Modified:	25 Sep 2019 04:22
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8474

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