Kempe Gowda, B. K. and Prasad, H. S. and Rangappa, K. S. and Channe Gowda, D. (2002) Hydrophobicity dependence of oxidation of tetrapeptides of elastin sequences with Mn(III): Synthesis, characterization, kinetics, and mechanistic study. International Journal of Chemical Kinetics, 34 (1). pp. 39-48. ISSN 1097-4601
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Abstract The analogues of elastin sequences, glycyl-glycyl-alanyl-proline (GGAP), glycyl-glycyl-phenylalanyl-proline (GGFP), and glycyl-glycyl-isoleucyl-proline (GGIP) were synthesized by classical solution phase method and characterized. The kinetics of oxidation of these tetrapeptides (TETP) by Mn(III) has been studied in the presence of sulphate ions in acidic solution at 25°C. The reaction was followed spectrophotometrically at λmax = 500 nm. A first-order dependence of rate on both Mn(III) and TETP was observed. The rate is independent of the concentration of the reduction product, Mn(II), and hydrogen ions. The effects of varying the dielectric constant of the medium and addition of anions such as sulphate, chloride, or perchlorate were studied. Activation parameters have been evaluated using Arrhenius and Erying plots. The oxidation products were isolated and characterized. A mechanism involving the reaction of TETP with Mn(III) in the rate-limiting step is suggested. An apparent correlation was noted between the rate of oxidation and the hydrophobicity of these sequences, where increased hydrophobicity results in increased rate of oxidation. © 2001 John Wiley \& Sons, Inc. Int J Chem Kinet 34: 39–48, 2002
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 24 Sep 2019 09:41 |
| Last Modified: | 24 Sep 2019 09:41 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/8463 |
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