Synthesis of novel 3-5-ethyl-2-(2-phenoxy-ethyl)-pyridin-5-substituted isoxazoline libraries via 1,3-dipolar cycloaddition and evaluation of antimicrobial activities

Gaonkar, Santosh L. and Rai, K. M. Lokanatha and Prabhuswamy, B. (2007) Synthesis of novel 3-5-ethyl-2-(2-phenoxy-ethyl)-pyridin-5-substituted isoxazoline libraries via 1,3-dipolar cycloaddition and evaluation of antimicrobial activities. Medicinal Chemistry Research, 15 (7). pp. 407-417. ISSN 1554-8120

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Abstract

A series of novel 3-5-ethyl-2-(2-phenoxy-ethyl)-pyridin-5-substituted isoxazolines were synthesized via 1,3-dipolar cycloaddition of in situ generated nitrile oxide from 4-2-(5-ethylpyridyl)-ethoxy-benzaldoxime with alkenes to obtain new heterocyclic libraries containing a pyridine moiety in addition to the isoxazoline ring. The newly synthesized compounds were screened for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Of the compounds studied, compounds 3c and 3f showed significant antibacterial as well as antifungal activity. Compounds 3e and 3g showed moderate activity. The title compounds represent a novel class of potent antimicrobial agents.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	24 Sep 2019 05:30
Last Modified:	19 Jan 2023 11:28
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8418

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