Nagaraja, P. and Arun Kumar, H. R. and Vasantha, R. A. and Yathirajan, H. S. (2002) Novel reagents for the sensitive spectrophotometric determination of flutamide, an anticancer drug in pharmaceutical preparations. International Journal of Pharmaceutics, 235 (1). 113 - 120. ISSN 1873-3476
Full text not available from this repository. (Request a copy)Abstract
Simple and sensitive spectrophotometric methods for the determination of flutamide (FLA) in either pure form or in its pharmaceutical preparations are described. The first method is based on the diazotisation of reduced FLA, followed by coupling with alcoholic iminodibenzyl (IDB) in acid medium to give a purple coloured product having a λmax of 570 nm. In the second method, the diazotisation of reduced FLA followed by coupling with 4-amino-5-hydroxy-2,7-naphthalenedisulphonic acid monosodium salt (AHND) in a buffer medium of pH 12, gives a red coloured product having a λmax of 520 nm. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed methods. Both the methods are highly reproducible and have been applied to a wide variety of pharmaceutical preparations and the results compare favourably with the reported method.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Flutamide, Spectrophotometry, Iminodibenzyl, AHND, Pharmaceuticals |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 24 Sep 2019 05:29 |
| Last Modified: | 24 Sep 2019 05:29 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/8417 |
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