Dinesh, N. D. and Nagaraja, P. and Made Gowda, N. M. and Rangappa, K. S. (2002) Extractive spectrophotometric methods for the assay of sildenafil citrate (Viagra) in pure form and in pharmaceutical formulations. Talanta, 57 (4). 757 - 764. ISSN 1873-3573
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Two simple and sensitive extractive spectrophotometric methods for the determination of sildenafil citrate (SC) are proposed. The methods are based on the formation of ion-association complexes of sildenafil citrate with bromocresol green (BCG, method A) and with chromoxane cyanine R (CCR, method B) in aqueous acidic buffer. The complex species, extractable to chloroform phase, were quantitatively measured at 415 and 460 nm for methods A and B, respectively. Beer's law was obeyed in the SC concentration range 1.25–25 μg ml−1 with a limit of detection 0.16 μg ml−1 and 1.5–60 μg ml−1 with a limit of detection 0.18 μg ml−1, respectively, for methods A and B. The methods have been successfully applied to the analysis of bulk drug and its tablets. No interference was observed from common pharmaceutical adjuvants.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Spectrophotometry, Sildenafil citrate, Bromocresol green, Chromoxane cyanine R, Ion-association complex |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 23 Sep 2019 08:16 |
| Last Modified: | 23 Sep 2019 08:16 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/8371 |
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