Novel coupling reagents for the sensitive spectrophotometric determination of nimesulide in pharmaceutical preparations

Nagaraja, P. and Yathirajan, H. S. and Arun Kumar, H. R. and Vasantha, R. A. (2002) Novel coupling reagents for the sensitive spectrophotometric determination of nimesulide in pharmaceutical preparations. Journal of Pharmaceutical and Biomedical Analysis, 29 (1). 277 - 282. ISSN 1873-264X

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Abstract

Novel coupling reagents are used for the sensitive spectrophotometric determination of nimesulide (NIME) in either pure form or in its pharmaceutical preparations. The methods are based on the diazotisation of reduced NIME, followed by either coupling with alcoholic iminodibenzyl (IDB) in acid medium to give a deep blue coloured product (λmax of 600 nm) or coupling with 3-aminophenol (AP) in acid medium to produce an orange red coloured product (λmax of 470 nm). Both the methods are highly reproducible and have been applied to a wide variety of pharmaceutical preparations and the results compare favourably with the reported method. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed methods.

Item Type:	Article
Uncontrolled Keywords:	Nimesulide, Spectrophotometry, Iminodibenzyl, 3-Aminophenol, Diazotisation, Coupling, Pharmaceuticals
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	23 Sep 2019 08:12
Last Modified:	01 Oct 2019 10:05
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8370

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