New spectrophotometric method for the determination of flutamide in pharmaceutical preparations

Nagaraja, P. and Sunitha, K. R. and Silwadi, M. F. (2000) New spectrophotometric method for the determination of flutamide in pharmaceutical preparations. Journal of Pharmaceutical And Biomedical Analysis, 23 (4). pp. 617-622. ISSN 0731-7085

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Abstract

A sensitive and simple spectrophotometric method for the determinations of reduction product of flutamide (FLA) is described. The method is based on the interaction of diazotized flutamide reduction product with N-(1-naphthyl) ethylenediamine dihydrochloride (NEDA) in neutral or resorcinol (RSL) in alkaline medium. Absorbance of the resulting chromophores is measured at 525 or 480 nm, respectively, and is stable for at least 7 days. The two coupling reagents are applied successfully for the determination of FLA in tablets. The common excipients used as additives in pharmaceutical preparations do not interfere with the determination. Results from the analysis of pure FLA and its commercial tablets by the proposed methods agree well with the reported method. (C) 2000 Elsevier Science B.V. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	flutamide; reduction; diazotization; N-(1-naphthyl) ethylenediamine; resorcinol; spectrophotometry
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 19 not found.
Date Deposited:	23 Sep 2019 06:14
Last Modified:	23 Sep 2019 06:14
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8350

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