Determination of drug content of pharmaceuticals containing ranitidine by titrimetry and spectrophotometry in non-aqueous medium

Basavaiah, K. and Nagegowda, P. and Ramakrishna, V. (2005) Determination of drug content of pharmaceuticals containing ranitidine by titrimetry and spectrophotometry in non-aqueous medium. ScienceAsia, 31 (3). pp. 207-214. ISSN 1513-1874

Text (Full Text) Determination of Drug Content.pdf - Published Version Restricted to Registered users only Download (106kB) | Request a copy

Abstract

ABSTRACT: Three simple, rapid, reliable and cost-effective methods based on titrimetry and spectrophotmetry in non-aqueous medium are described for the determination of ranitidine in pharmaceuticals. In titrimetry, the drug dissolved in glacial acetic acid was titrated with acetous perchloric acid with visual and potentiometric end point detection, crystal violet being used as indicator for visual titration. Spectrophotometry involved adding different amounts of the drug to a fixed amount of perchloric acid-crystal violet mixture followed by measurement of absorbance at 570 nm. The absorbance was found to increase linearly with the concentration of the drug and formed the basis for quantification. The titrimetric methods are applicable over 1-15 mg range of ranitidine, and in spectrophotometry, calibration graph was linear from 10 to 70 g ml-1. The apparent molar absorptivity is calculated to be 2.2 x 103 l mol-1 cm-1 and the calculated Sandell sensitivity is 161.7 ng cm-2. The limits of detection and quantification are found to be 1.07 and 3.58 g ml-1, respectively. The procedures were used to determine ranitidine in pharmaceutical products and the results were found to be in good agreement with those obtained by the reference method. Associated pharmaceutical materials did not interfere. The accuracy and reliability of the methods were further ascertained by recovery studies via standard-addition technique with percent recoveries in the range 96.3 to 102.5 %.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	16 Sep 2019 11:11
Last Modified:	16 Sep 2019 11:11
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8183

Actions (login required)

View Item