Synthesis and crystallographic analysis of benzophenone derivatives—The potential anti-inflammatory agents

Venu, T. D. and Shashikanth, S. and Shaukath Ara Khanum and Naveen, S. and Aiysha Firdouse and Sridhar, M. A. and Shashidhara Prasad, J. (2007) Synthesis and crystallographic analysis of benzophenone derivatives—The potential anti-inflammatory agents. Bioorganic & Medicinal Chemistry, 15 (10). 3505 - 3514. ISSN 0968-0896

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Official URL: https://doi.org/10.1016/j.bmc.2007.02.051

Abstract

Fries rearrangement of substituted phenyl benzoates 1a–j to substituted hydroxy benzophenones 2a–j was achieved in excellent yield. Further benzoylation of 2a–j to benzoyloxy benzophenones 4a–n, a benzophenone analogue was achieved in good yield. All the newly synthesized compounds were evaluated for their anti-inflammatory activity and were compared with standard drugs. Out of the compounds studied, the compounds 4c, 4e, 4g, 4h and 4k with chloro and methyl substituents at para position showed more potent activity than the standard drugs at all doses tested.

Item Type: Article
Uncontrolled Keywords: Synthesis, Crystal structure, Benzoyloxy benzophenone, Anti-inflammatory activity
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 16 Sep 2019 09:55
Last Modified: 01 Jun 2023 10:39
URI: http://eprints.uni-mysore.ac.in/id/eprint/8170

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