Basavaiah, K. and Prameela, H. C. (2003) Spectrophotometric determination of salbutamol sulfate (SBS) and pyrantel pamoate (PRP) in bulk drugs and pharmaceuticals. Chemia Analityczna, 48 (2). pp. 327-334. ISSN 0009-2223
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A simple spectrophotometric method for the determination of salbutamol sulfate and pyrantel pamoate is described. The absorbance of the blue-coloured species produced when the drugs react with the. Folin-Ciocalteu reagent in alkaline medium is measured. The method is applicable to the concentration range of. 1.0-12.0 mug mL(-1) and 2.5-25 mug mL(-1) for salbutamol sulfate and pyrantel pamoate, respectively. The apparent molar absorptivities and Sandell sensitivities of the coloured species were found to be 2.33 x 10(4) L mol(-1) cm(-1) and 24.68 ng cm(-2), and 1.45 x 10(4) L mol(-1) cm(-1) and 42.56 ng cm(-2) for salbutamol sulfate and pyrantel pamoate, respectively. Statistical data treatment has proved the accuracy and precision of the method to be sufficient. Excipients added to the studied pharmaceuticals did not introduce any interferences. The procedure described was successfully applied to the determination of the bulk drugs and their pharmaceutical formulations.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | LA manjunath user |
| Date Deposited: | 13 Sep 2019 06:58 |
| Last Modified: | 18 Dec 2019 11:22 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/8094 |
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