Chidan Kumar, C. S. and Naveen, S. and Venkatachalapathy, R. and Anilraj, K. N. and Chandraju, S. (2013) Crystal and molecular structure studies of cinnarizinium dimaleate. Der Pharma Chemica, 5 (1). pp. 51-54.
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Abstract
The title salt systematic name: 1-diphenylmethyl-4-(2E)-3-phenylprop-2-en-1-ylpiperazine-1,4-diium bis (hydrogen maleate), crystallizes in the monoclinic space group P21, with a = 9.940 (2) à , b = 27.115 (6) à , c = 11.802 (3) à , β = 98.403 (3)°, V = 3146.8 (12) à and Z = 2. The piperazine ring is protonated at both the N atoms and adopts a distorted chair conformation. The sum of the bond angles around the piperazine N atoms N1 and N2 indicates that they are sp3 hybridized. The structure exhibits both intra- and intermolecular hydrogen bonds of the type O-H O and N-H O.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | article, unclassified drug, drug structure, hybridization, crystallization, X ray crystallography, hydrogen bond, piperazine derivative, crystal structure, drug conformation, nitrogen, maleic acid, hydrogen, 1 diphenylmethyl 4 (3 phenylprop 2 en 1 yl)piperazine 1, 4 diium bis(hydrogen maleate), chemical bond, cinnarizine, proton transport |
| Subjects: | D Physical Science > Sugar Technology |
| Divisions: | PG Centre Mandya > Sugar Technology |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 13 Sep 2019 05:28 |
| Last Modified: | 13 Sep 2019 05:28 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/8026 |
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