Deepakumari, H. N. and Mallegowda, S. M. and Vinay, K. B. and Revanasiddappa, H. D. (2013) Simple and extraction-free spectrophotometric methods for risperidone in pure form and in dosage forms. Chemical Industry and Chemical Engineering Quarterly, 19 (1). pp. 121-128.
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Two simple, sensitive and extraction-free spectrophotometric methods are described for the estimation of risperidone (RSP) in both pure and in pharmaceutical preparations. The proposed methods are based on the formation of ion-pair complex between RSP and the dyes bromophenol blue (BPB) in method A and phenol red (PR) in method B, at room temperature, to form yellow colored products which show maximum absorbance at 410 and at 400 nm in methods A and B, respectively. Beer's law was obeyed in the concentration range of 0.5-10 and 0.5-25 μg mL-1 in methods A and B with apparent molar absorptivities of 3.44�104 and 0.85�104 L moL-1 cm-1, respectively. The limit of detection for method A is found to be 0.0056 and for method B is 0.132 μg mL-1. The composition of the ion-pairs was established by Job's method and it was found to be 1:1 for both the methods A and B. The proposed methods have been applied successfully to the determination of RSP in pharmaceutical preparations. The results were statistically compared with those of a reference method by applying the Student's t-test and F-test. The methods developed were validated for accuracy and precision by performing recovery experiments via standard addition technique.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 13 Sep 2019 05:17 |
| Last Modified: | 13 Sep 2019 05:17 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/8025 |
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