Haddadi, M. and Jahromi, S. R. and Shivanandappa, T. and Ramesh, S. R. (2013) Decalepis hamiltonii root extract attenuates the age-related decline in the cognitive function in Drosophila melanogaster. Behavioural Brain Research, 249. pp. 8-14. ISSN 0166-4328
Full text not available from this repository. (Request a copy)Abstract
Age-associated accumulation of oxidative damage linked to decline of antioxidant defense mechanism, leads to impairment of cognitive function in many organisms. These damages can pass through generations and affect the cognitive quality of progenies. In Drosophila, classical olfactory conditioning results in the formation of different types of memory. Age-related memory impairment (AMI) causes reduction in middle term memory (MTM) and parental senescence causes decline in short-term memory (STM) of the offspring. We have further examined the neuromodulatory effect of Decalepis hamiltonii (Dh) root extract, which is a cocktail of novel antioxidant molecules, on the biochemical oxidative defenses in relation to cognitive ability of the aged flies and their offspring. There is a strong correlation between the age-related decline in the activity of the antioxidant enzymes and the lower cognitive ability of the aged flies and their offspring. Feeding of aged flies in the diet containing 0.1% Dh, markedly enhances the cognitive ability of both aged flies and their offspring which is associated with enhanced antioxidant defenses as evident for the activity of superoxide dismutase (SOD) and catalase. Our findings, for the first time, show that the antioxidant-rich Dh root extract attenuates the age-related decline in cognitive ability of Drosophila, and also shows ameliorative effect on the memory of the offspring.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | article, priority journal, animal experiment, controlled study, nonhuman, Drosophila melanogaster, antioxidant activity, plant extract, unclassified drug, plant root, Animals, antioxidant, catalase, enzyme activity, superoxide dismutase, Animal, Oxidative Stress, Plant Extracts, Oxidation-Reduction, oxidation, Behavior, larva, Apocynaceae, Decalepis hamiltonii, Plant Roots, correlation analysis, aging, Aging, progeny, cognitive defect, animal behavior, Decalepis hamiltonii extract, Motor Activity, Learning, Cognition, conditioning, embryo, neuromodulation, Olfactory Perception, smelling |
| Subjects: | B Life Science > Zoology |
| Divisions: | Department of > Zoology |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 17 Sep 2019 07:22 |
| Last Modified: | 17 Sep 2019 07:22 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7992 |
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