Synthesis of pyrimidones and evaluation of their xanthine oxidase inhibitory and antioxidant activities

Gurupadaswamy, H. D. and Girish, V. and Zameer, F. and Hegdekatte, R. and Chauhan, J. B. and Khanum, S. A. (2013) Synthesis of pyrimidones and evaluation of their xanthine oxidase inhibitory and antioxidant activities. Archiv der Pharmazie, 346 (11). pp. 805-811.

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Abstract

The increasing prevalence of gout has been accompanied by a growing number of patients intolerant to or with disease refractory to the available urate-lowering therapies. This metabolic disease is a common disease with a higher prevalence in men older than 30 years and in women older than 50 years. These findings highlight the need for emerging treatments to effectively lower urate levels. In this view, we describe the xanthine oxidase (XO) inhibitory activities of the synthesized compounds 5a-j and also their antioxidant activities. Compounds 5c, 5d, 5f, 5h, and 5j exhibited good inhibitory activities against XO. On the other hand, compounds 5g and 5j exhibited moderate antioxidant activity. In order to find new urate-lowering compounds, the xanthine oxidase (XO) inhibitory and antioxidant activities of the newly synthesized pyrimidones 5a-j were evaluated. Compounds 5c, 5d, 5f, 5h, and 5j exhibited good inhibitory activities against XO. In addition, compounds 5g and 5j showed moderate antioxidant activity.

Item Type:	Article
Uncontrolled Keywords:	article, human, priority journal, controlled study, rat, comparative study, antioxidant activity, lipid peroxidation, chemical structure, Animals, antioxidant, Antioxidants, enzyme inhibition, Rats, drug synthesis, structure activity relation, Molecular Structure, Structure-Activity Relationship, Humans, animal, metabolism, synthesis, oxidation, molecular docking, Molecular Docking Simulation, room temperature, prevalence, chelation, Lipid Peroxidation, scavenger, xanthine oxidase, Free Radical Scavengers, uric acid, pyrimidinone derivative, antagonists and inhibitors, drug effects, enzyme inhibitor, Enzyme Inhibitors, allopurinol, Xanthine Oxidase, xanthine oxidase inhibitor, antigout agent, Gout Suppressants, hydrogen, molybdenum, Pyrimidinones, Uric Acid
Subjects:	C Chemical Science > Chemistry
Divisions:	Yuvaraj college > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	23 Sep 2019 10:05
Last Modified:	23 Sep 2019 10:05
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7951

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