Ananda Kumar, C. S. and Benaka Prasad, S. B. and Vinaya, K. and Chandrappa, S. and Thimmegowda, N. R. and Sunil Kumar, Y. C. and Sanjay Swarup and Rangappa, K. S. (2009) Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines. European Journal of Medicinal Chemistry, 44 (3). pp. 1223-1229.
Full text not available from this repository. (Request a copy)Abstract
In order to explore the antiproliferative effect associated with the piperazine framework, several 1-benzhydrylpiperazine derivatives 8(a–d), 9(a–d) and 10(a–h) were synthesized. Variation in the functional group at N-terminal of the piperazine led to three sets of compounds, bearing the sulfonyl, amide and thiourea, respectively. Their chemical structures were confirmed by 1H NMR, LCMS, IR and elemental analysis. The antiproliferative effect of the compounds were evaluated in vitro using the MTT colorimetric method against one normal cell line (NF-103 skin fibroblast cells) and four human cancer cell lines (MCF-7 breast carcinoma cell line, HepG-2 hepatocellular carcinoma cell line, HeLa cervix carcinoma cell line and HT-29 colon carcinoma cell line) for the time period of 24 h. Among the series, four compounds exhibited interesting growth inhibitory effects against all four cell lines.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1-Benzhydrylpiperazine derivatives and Sulfonyl chlorides and MTT assay and Antiproliferative activity and Cell proliferation and Carcinoma cell lines |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 11 Sep 2019 06:37 |
| Last Modified: | 11 Sep 2019 06:37 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7920 |
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