Synthesis and molecular structure analysis of venlafaxine intermediate and its analog

Kavitha, C. V. and Lakshmi, S. and Basappa and Mantelingu, K. and Sridhar, M. A. and Shashidhara Prasad, J. and Rangappa, K. S. (2005) Synthesis and molecular structure analysis of venlafaxine intermediate and its analog. Journal of Chemical Crystallography, 35 (12). pp. 957-963. ISSN 1572-8854

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Abstract

1-(cyano-(4-methoxyphenyl) methyl cyclohexanol(2), C24H32N2O2, a Venlafaxine intermediate is found to crystallize in both monoclinic(2a) and orthorhombic(2b) crystal systems. The form2a crystallizes in the space groupC2/c with the cell parametersa = 23.506(3),b = 5.550(3),c = 23.192(3), and β = 115.116(2)^∘.2b crystallizes in space groupP212121 with cell parametersa = 5.7850(6),b = 11.2680(6), andc = 20.6730(19). The intermolecular hydrogen bonding in the case of the monoclinic polymorph leads to the formation of dimer. The synthesis, characterization, and crystal structure studies of Venlafaxine analog 1-[2-1-(4-dimethylamino-phenyl)-ethylideneamino]-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol(4) is reported.4 crystallizes inP―1 space group with cell parametersa = 10.801(7),b = 12.078(7),c = 9.928(5), α = 96.12(5)^∘, β = 110.49(5)^∘, and γ = 112.42(6)^∘.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	04 Sep 2019 07:43
Last Modified:	04 Sep 2019 07:43
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7524

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