A rapid and convenient synthetic route to novel 1,5-benzodiazepine derivatives of 5-methyl-3-phenyl-2-oxo-Δ4-1,3,4-oxadiazolines from p-acetylphenylsydnone and their pharmacological activity

Kamble, Ravindra R. and Sudha, Belagur S. (2006) A rapid and convenient synthetic route to novel 1,5-benzodiazepine derivatives of 5-methyl-3-phenyl-2-oxo-Δ4-1,3,4-oxadiazolines from p-acetylphenylsydnone and their pharmacological activity. Chinese Journal of Chemistry, 24 (1). pp. 79-84. ISSN 1614-7065

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Abstract

Abstract A simple and high yielding method for the integration of 1,5-benzodiazepines integrated with 5-methyl-2-oxo-3-phenyl-Δ4-1,3,4-oxadiazolines in 75%–90% yield by microwave irradiation is devised. Microwave-accelerated reaction was compared with thermal method. All the compounds were characterized by physical, analytical and spectral (IR, 1H NMR, MS) data. Title compounds were screened for preliminary pharmacological activities.

Item Type:	Article
Uncontrolled Keywords:	p-acetylphenylsydnone, 1,3-dipolar cycloaddition, 1,5-diazepine, Michael addition, microwave irradiation, thermal method
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	28 Aug 2019 10:02
Last Modified:	28 Aug 2019 10:03
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7254

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