Gaonkar, Santosh L. and Rai, K. M. Lokanatha and Shetty, Suchetha N. (2009) Microwave-assisted synthesis and evaluation of anti-inflammatory activity of new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives. Medicinal Chemistry Research, 18 (3). pp. 221-230. ISSN 1054-2523
Full text not available from this repository. (Request a copy)Abstract
A series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives bearing potentially bioactive substituents were synthesized by microwave irradiation method in good yield compared with conventional method. The synthesized compounds were screened for their anti-inflammatory activity and were compared with a standard drug. The compounds demonstrated potent to weak anti-inflammatory activity. Of the compounds studied, compounds 6i and 6d showed potent activity comparable to the standard drug ibuprofen at the same dose in carrageenan-induced paw edema in rat model.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Anti-inflammatory; Imidazole-carbaldehyde; Microwave irradiation |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 28 Aug 2019 07:20 |
| Last Modified: | 19 Jan 2023 06:03 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7226 |
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