In vitro antioxidant activity of dibenz[b,f]azepine and its analogues

Vijay Kumar, H. and Gnanendra, C. R. and Naik, Nagaraja and Channe Gowda, D. (2008) In vitro antioxidant activity of dibenz[b,f]azepine and its analogues. E-Journal of Chemistry, 5 (S2). pp. 1123-1132. ISSN 2090-9810

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Abstract

Dibenz[b,f]azepine and its five derivatives bearing different functional groups were synthesized by known methods. The compounds thus synthesized were evaluated for antioxidant potential through different in vitro models such as (DPPH) free radical scavenging activity, ß-carotene-linoleic acid model system, reducing power assay and phosphomolybdenum method. Under our experimental condition among the synthesized compounds dibenz[b,f]azepine (a) and 10-methoxy-5H-dibenz[b,f]azepine (d) exhibited potent antioxidant activity in concentration dependent manner in all the above four methods. Butylated hydroxyl anisole (BHA) and ascorbic acid (AA) were used as the reference antioxidant compounds. The most active compounds like dibenz[b,f]azepine and its methoxy group substituent have shown more promising antioxidant and radical scavengers compared to the standards like BHA and ascorbic acid. It is conceivable from the studies that the tricyclic amines, i.e. dibenz[b, f]azepine and some of its derivatives are effective in their antioxidant activity properties.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	27 Aug 2019 10:09
Last Modified:	27 Aug 2019 10:09
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7142

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