Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation

Thimmegowda, N. R. and Nanjunda Swamy, S. and Ananda Kumar, C. S. and Sunil Kumar, Y. C. and Chandrappa, S. and Yip, George W. and Rangappa, K. S. (2008) Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Bioorganic & Medicinal Chemistry Letters, 18 (1). 432 - 435. ISSN 1464-3405

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Official URL: https://doi.org/10.1016/j.bmcl.2007.08.078

Abstract

A novel series of trisubstituted benzimidazole and its precursors (3–7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor.

Item Type: Article
Uncontrolled Keywords: Trisubstituted benzimidazole, MDA-MB-231, Cell proliferation
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 26 Aug 2019 11:23
Last Modified: 26 Aug 2019 11:23
URI: http://eprints.uni-mysore.ac.in/id/eprint/7079

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