Basavaiah, K. and Tharpa, Kalsang and Rajendra Prasad, N. and Hruyanna, S. G. and Vinay, K. B. (2009) Determination of stavudine in pharmaceuticals by titrimetry and spectrophotometry using N-bromosuccinimide and three dyes- methyl orange, indigo carmine and thymol blue. Proceedings of The National Academy of Sciences India Section A-Physical Sciences, 79A. pp. 231-236. ISSN 0369-8203
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Titrimetric and spectrophometric methods were developed for the determination of stavudine (STV) in bulk drug and in dosage forms using N-bromosuccinimide (NBS) and methyl orange, indigo can-nine and thymol blue as reagents. The methods are based on the oxidation of STV by a measured excess of NBS in HCl medium followed by the determination of residual oxidant by iodometric titrimetry, and by reacting with methyl orange, indigo carmine or thymol blue in spectrophometry. The methods were validated for linearity, limit of detection (LOD) and quantification (LOQ) and accuracy and precision. The validated methods were applied to the determination of STV in tablets and capsules with satisfactory results.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | stavudine; determination; N-bromosuccinimide; dye; formulations |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 23 Aug 2019 09:28 |
| Last Modified: | 23 Aug 2019 09:28 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/6961 |
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