MTA1 induced angiogenesis, migration and tumor growth is inhibited by Glycyrrhiza glabra

Sachin Raj, M. N. and Sheela, M. L. and Yashaswini, B. and Akhilesh Kumar and Bharathi P. Salimath (2012) MTA1 induced angiogenesis, migration and tumor growth is inhibited by Glycyrrhiza glabra. IOSR Journal of Pharmacy, 2 (4). pp. 34-43. ISSN 2250-3013

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Abstract

Angiogenesisis an important host process that interacts with cancer cells to promote growth, invasion and metastasis. Vascular endothelialgrowth factor (VEGF) andMetastasis Associated protein (MTA1) are known to play a major role in angiogenesis.The recombinant VEGF and MTA1 proteinswere used to induce proliferation and cell migration in MDA-MB-231 cells. Here we investigated the antiangiogenic and antitumor activity of G glabraF6 (G1) on VEGF and MTA1 induced angiogenesis. The angio inhibitory activity of G.glabraF6 (G1)was confirmed by its inhibition of angiogenesis in in vivo assays, peritoneal and chorioallantoic membrane assay. Reduction in the levels of the cytokine VEGF and microvessel density count in the peritoneum of mice treated with G.glabraF6 (G1)indicated that the plant extract decreased VEGF production. It also inhibits the neovascularization in CAM induced by VEGF and MTA1. These findings not only suggest a potential role of VEGF or MTA1 in tumour angiogenesis but itisalso an effective beginning to explore mechanism of metastasis and cancer therapy strategy targeting MTA1.Our results suggest that the extract from the roots of G.glabramay be a potential supplemental source for cancer therapy.

Item Type:	Article
Subjects:	B Life Science > Biotechnology
Divisions:	Department of > Biotechnology
Depositing User:	C Swapna Library Assistant
Date Deposited:	21 Aug 2019 06:33
Last Modified:	22 Aug 2022 09:15
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6850

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