Vinaya, K. and Naika, Raja and Ananda Kumar, C. S. and Ranganath, S. R. and Benaka Prasad, S. B. and Krishna, V. and Rangappa, K. S. (2009) Synthesis and anti-inflammatory activity of novel (4-hydroxyphenyl)(2,4-dimethoxyphenyl) methanone derivatives. ARCHIV DER PHARMAZIE, 342 (8). pp. 476-483. ISSN 1521-4184
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In the scope of the research program aiming to perform the synthesis and pharmacological evaluation of novel possible anti-inflammatory compounds, in this manuscript, we report the synthesis of novel carboxamide 9a-d and thioamide 10a-d derivatives from the benzophenone and piperidine nucleus. Variation in the functional group at the N-terminal of piperidine led to two sets of compounds, bearing the carboxamide and thioamide, respectively. The characterization of this new class of compounds was performed with H-1-NMR, LC-MS, IR, and elemental analysis. The newly synthesized compounds were screened for their anti-inflammatory activity by carrageenan-induced foot pad oedema assay and were compared with a standard drug. All the compounds exhibited anti-inflammatory activity at the dose of 30 mg/kg p.o. with varying degree from 52 to 67% inhibition of oedema. The compounds 9d and 10d with dichloro and fluoro substitution showed more potent activity at 30 mg/kg p.o. than the standard drug.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Anti-inflammatory activity; Isocyanates; Isothiocyanates; Piperidine |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 20 Aug 2019 06:45 |
| Last Modified: | 15 Jul 2022 09:52 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/6803 |
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