Synthesis and antimicrobial studies of a new series of 2-4-2-(5-ethylpyridin-2-yl)ethoxyphenyl-5-substituted-1,3,4-oxadiazoles

Gaonkar, Santosh L. and Rai, K. M. Lokanatha and Prabhuswamy, B. (2006) Synthesis and antimicrobial studies of a new series of 2-4-2-(5-ethylpyridin-2-yl)ethoxyphenyl-5-substituted-1,3,4-oxadiazoles. European Journal of Medicinal Chemistry, 41 (7). 841 - 846. ISSN 1768-3254

Text (Full Text) Synthesis and antimicrobial.pdf - Published Version Restricted to Registered users only Download (173kB) | Request a copy

Abstract

A series of novel 2-4-2-(5-ethylpyridin-2-yl)ethoxyphenyl-5-substituted-1,3,4-oxadiazoles were synthesized by the oxidative cyclisation of hydrazones derived from 4-2-(5-ethylpyridin-2-yl)ethoxybenzaldehyde and aroylhydrazines using chloramine-T as oxidant. IR, NMR and elemental analysis characterized the newly synthesized compounds. The synthesized compounds were evaluated for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Out of the compounds studied, compounds 8c and 8d showed significant inhibition. Compounds 8b, 8f, 8k and 8e showed moderate activity. The minimum inhibitory concentration of the compounds was in the range of 8–26 μg ml–1 against bacteria and 8–24 μg ml–1 against fungi. The title compounds represent a novel class of potent antimicrobial agents.

Item Type:	Article
Uncontrolled Keywords:	Synthesis, 1,3,4-oxadiazoles, Antimicrobial activity, Chloramine-T
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	17 Aug 2019 10:19
Last Modified:	19 Jan 2023 11:29
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6684

Actions (login required)

View Item