Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

Venu, T. D. and Khanum, S. A. and Aiysha Firdouse, . and Manuprasad, B. K. and Sheena, S. and Mohamed, Riyaz and Vishwanth, B. S. (2008) Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines. Bioorganic & Medicinal Chemistry Letters, 18 (15). 4409 - 4412. ISSN 1464-3405

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Official URL: https://doi.org/10.1016/j.bmcl.2008.06.061

Abstract

Abstract-Reaction of 6a–f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a–f in excellent yield. The newly synthesized heterocycles were characterized by IR, 1H NMR, and mass spectral data. Compounds 7a–f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.

Item Type: Article
Uncontrolled Keywords: Synthesis, Pyrimidines, Anti-inflammatory activity
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 17 Aug 2019 10:16
Last Modified: 16 Jul 2022 07:01
URI: http://eprints.uni-mysore.ac.in/id/eprint/6682

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