Synthesis of 5-(4 `-aroyl)-aryloxy methyl-4H-(1,2,4)-triazolin-3-thiol and their biological activity.

Sudha, B. S. and Shashikanth, S. and Khanum, S. A. (2004) Synthesis of 5-(4 `-aroyl)-aryloxy methyl-4H-(1,2,4)-triazolin-3-thiol and their biological activity. HETEROCYCLIC COMMUNICATIONS, 10 (1). pp. 85-88. ISSN 0793-0283

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Abstract

5-(4'-aroyl)-aryloxy methyl-4H-1,2, 4)-triazolin-3-thiols were synthesized by using substituted phenyl benzoates as the starting material. Phenyl benzoates on Fries rearrangement gave p-hydroxy benzophenones which on treatment with ethyl bromoacetate in presence of anhydrous potassium carbonate and dry acetone gave corresponding benzoyl phenyloxy esters in excellent yield. Esters were refluxed with thiosemicarbazide in presence of acetic anhydride gave cyclized title compounds. Supports for the structures of the synthesized compounds have been provided by their elemental analysis and spectral data. The newly synthesized compounds were screened for antibacterial and antifungal activities. Key words: Aroyl aryloxy esters, triazolin-3-thiols.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	19 Aug 2019 12:26
Last Modified:	11 Dec 2019 11:04
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6633

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