A simple and efficient method for the synthesis of 1,2-benzisoxazoles: A series of its potent acetylcholinesterase inhibitors

Basappa and Mantelingu, K. and Sadashiva, M. P. and Rangappa, K. S. (2004) A simple and efficient method for the synthesis of 1,2-benzisoxazoles: A series of its potent acetylcholinesterase inhibitors. Indian journal of chemistry, 43 (9). pp. 1954-1957. ISSN 0019-5103

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Abstract

A simple and efficient method for the synthesis of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride is achieved. This reaction involves hydroxylamine sulfate/KOH mediated, in situ generated oxime formation and its subsequent internal cyclisation followed by alkaline hydrolysis of N-protected ketone in one step. Synthesis of 1,2-benzisoxazole analogues is described and they are found to be potent acetylcholinesterase inhibitors.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 03 Sep 2019 11:10
Last Modified: 28 Dec 2020 06:07
URI: http://eprints.uni-mysore.ac.in/id/eprint/6548

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