Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines

Sadashiva, M. P. and Mallesha, H and Hitesh, N. A. and Rangappa, K. S. (2004) Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines. Bioorganic and Medicinal Chemistry, 12 (24). pp. 6389-6395. ISSN 0968-0896

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Abstract

Cycloaddition of C-imidazolyl-N-phenylnitrotles with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against E moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	antimicrobial properties; synthesis; nitrones; isoxazolidine derivatives; cycloaddition
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	05 Sep 2019 07:22
Last Modified:	05 Sep 2019 07:22
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6505

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