Konger, Raymond L. and Marathe, Gopal K. and Yao, Yongxue and Zhang, Qiwei and Travers, Jeffrey B. (2008) Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. Prostaglandins & Other Lipid Mediators, 87 (1). 1 - 8. ISSN 1098-8823
Full text not available from this repository. (Request a copy)Abstract
Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Oxidation, Ultraviolet rays, Peroxisome proliferator-activated receptor gamma, Platelet-activating factor receptor, Glycerophosphoscholines |
| Subjects: | C Chemical Science > Biochemistry |
| Divisions: | Department of > Biochemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 16 Aug 2019 07:46 |
| Last Modified: | 16 Aug 2019 07:46 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/6430 |
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