Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-bis(4-fluorophenyl)-methylpiperazine

Chandra, J. N. Narendra Sharath and Sadashiva, C. T. and Kavitha, C. V. and Rangappa, K. S. (2006) Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-bis(4-fluorophenyl)-methylpiperazine. Bioorganic & Medicinal Chemistry, 14 (19). 6621 - 6627. ISSN 1464-3391

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Abstract

A series of novel substituted 1-bis(4-fluorophenyl)-methylpiperazine derivatives (4a–g) and (5h–m) have been synthesized. The synthesized compounds were characterized by IR and 1H NMR. All the synthesized compounds were evaluated in vitro for their efficacy as antimicrobial agents against representative strains of Gram-positive (Staphylococcus aureus ATCC 25953, Streptococcus pneumoniae ATCC 49619, Bacillus cereus 11778, and Bacillus subtilis 6051) and Gram-negative bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 2853, Proteus vulgaris ATCC 2853, and Salmonella typhi ATCC 9484) by paper disc diffusion and microdilution methods. Among the newly synthesized compounds 4e, 5l, and 5m showed potent antimicrobial activities, when compared to the standard drug.

Item Type:	Article
Uncontrolled Keywords:	1-Bis(4-fluorophenyl)-methylpiperazine derivatives, Antibacterial, Paper disc diffusion method, Minimum inhibitory concentration
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	12 Aug 2019 08:16
Last Modified:	12 Aug 2019 08:16
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6289

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