Synthesis and In Vitro antiproliferative activity of 2-methyl-3-(2-piperazin-1-yl-ethyl)-pyrido1,2-apyrimidin-4-one derivatives against human cancer cell lines

Mallesha, L. and Mohana, K. N. and Veeresh, B. and Alvala, Ravi and Mallika, Alvala (2012) Synthesis and In Vitro antiproliferative activity of 2-methyl-3-(2-piperazin-1-yl-ethyl)-pyrido1,2-apyrimidin-4-one derivatives against human cancer cell lines. Archives of Pharmacal Research, 35 (1). pp. 51-57. ISSN 1976-3786

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Abstract

A series of new 2-methyl-3-(2-piperazin-1-yl-ethyl)-pyrido1,2-apyrimidin-4-one derivatives 6a-j were synthesized by a nucleophilic substitution reaction of 2-methyl-3-(2-piperazin-1-ylethyl)-pyrido1,2-apyrimidin-4-one with various sulfonyl chlorides. The compounds were characterized by different spectral studies. All the compounds were evaluated for their antiproliferative effect using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay method against four human cancer cell lines (K562, Colo-205, MDA-MB 231, IMR-32) for the time period of 24 h. Among the series, compounds 6d, 6e and 6i showed good activity on all cell lines except K562, whereas the other compounds in the series exhibited moderate activity. Compound 6d could be a potential anticancer agent and therefore deserves further research.

Item Type:	Article
Uncontrolled Keywords:	Piperazine, Sulfonyl chlorides, MTT assay, Antiproliferative activity, Human cancer cell lines
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	29 Jul 2019 06:07
Last Modified:	29 Jul 2019 06:07
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6151

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