In-Vitro release study of metoprolol succinate from the bioadhesive films of pullulan-polyacrylamide blends

Vishwanath, Bhat and Shivakumar, H. R. and Rai, Sheshappa K. and Ganesh, S. and Prasad, P. and Guru, G. S. and Bhavya, B. B. (2012) In-Vitro release study of metoprolol succinate from the bioadhesive films of pullulan-polyacrylamide blends. International Journal of Polymeric Materials and Polymeric Biomaterials, 61 (4). pp. 300-307. ISSN 1563-535X

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Abstract

In the present work, an attempt has been made to investigate the drug release profile of pullulan-polyacrylamide blend films with metoprolol succinate as a model drug. The drug diffusion behavior of pullulan/polyacrylamide films has been established by an open glass diffusion cell at 37 ± 1°C. The diffusion rate of the drug was determined by UV/visible spectroscopy. The kinetics of drug release are fitted to the Higuchi and Koresmeyer–Peppas model. The drug release kinetics for the blend was found to be fast and follows Fickian mechanism. This blend could be a promising approach for formulating a transdermal drug delivery system for immediate release with good film-forming property.

Item Type:	Article
Uncontrolled Keywords:	Drug release, FTIR, Hydrophilic, In vitro, Polymer
Subjects:	M Polymer Science > Polymer Science
Divisions:	PG Centre Mandya > Polymer Science
Depositing User:	C Swapna Library Assistant
Date Deposited:	29 Jul 2019 05:58
Last Modified:	16 Jul 2022 06:57
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6146

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