Application of Bromate-Bromide mixture as a green Brominating agent for the Spectrophotometric determination of Atenolol in Pharmaceuticals

Prashanth, K. N. and Basavaiah, K. and Abdulrahman, S. A. M. and Rajendraprasad, N. and Vinay, K. B. (2012) Application of Bromate-Bromide mixture as a green Brominating agent for the Spectrophotometric determination of Atenolol in Pharmaceuticals. Chemical Industry and Chemical Engineering Quarterly, 18 (1). pp. 43-52. ISSN 2217-7434

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Abstract

Two highly sensitive spectrophotometric methods are proposed for the quantification of atenolol (ATN) in pure drug as well as in pharmaceutical formulations. The methods are based on the bromination reaction of ATN with a known excess of bromate-bromide mixture in acid medium followed by the determination of unreacted bromine. The residual bromine is determined by its reaction with excess iodide and the liberated iodine (l(3)(-)) is either measured at 360 nm (method A) or reacted with starch followed by the measurement of the starch-iodine chromogen at 570 nm (method B). Under the optimum conditions, ATN could be assayed in the concentration ranges of 0.5-90 and 0.3-6.0 mu g mL(-1) for methods A and B, respectively, with corresponding molar absorptivity values of 2.36x10(4) and 289x10(4) L mol(-1) cm(-1). Sandell's sensitivity values are found to be 0.0113 and 0.0092 mu g/cm(2) for methods A and B, respectively. The proposed methods were successfully applied to the analysis of different commercial brands of pharmaceutical formulations and the results obtained by the proposed methods were in good agreement with those obtained using the reference method The reliability of the methods was further ascertained by recovery studies using standard- addition method.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 26 Jul 2019 09:31
Last Modified: 23 Jun 2022 06:19
URI: http://eprints.uni-mysore.ac.in/id/eprint/5928

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