Simple and rapid spectrophotometric assay of levocetirizine in pharmaceuticals through charge-transfer complexation using chloranilic acid and 2,3-dichloro-5,6-dicyanoquinone as π-acceptors

Basavaiah, K. and Raghu, M. S. and Vinay, K. B. (2012) Simple and rapid spectrophotometric assay of levocetirizine in pharmaceuticals through charge-transfer complexation using chloranilic acid and 2,3-dichloro-5,6-dicyanoquinone as π-acceptors. Bulletin of the Chemical Society of Ethiopia, 26 (3). pp. 319-328. ISSN 1726-801X

Text (Full Text) SIMPLE AND RAPID SPECTROPHOTOMETRIC ASSAY.pdf - Published Version Restricted to Registered users only Download (218kB) | Request a copy

Abstract

Simple, rapid, selective and fairly sensitive method is described for the determination of levocetirizine (LCTZ) in pure form and in its dosage forms. The method is based on the formation of intensely colored charge-transfer (CT) complexes between LCTZ as donor with two π acceptors, chloranilic acid (CAA) and 2,3-dichloro-5,6-dicyanoquinone (DDQ) in acetonitrile-dioxane medium. The colored products were measured at 520 nm (CAA) and 590 nm (DDQ). Optimization of experimentation conditions is described. Beer’s law is obeyed over the concentration ranges 3-120 and 2-80 µg mL-1 for CAA and DDQ reagents, respectively, with corresponding molar absorptivity values of 4.0×103 and 5.5×103 L mol cm-1. The limits of quantification (LOQ) are 2.99 and 1.69 µg mL-1 for above reagents, respectively. Other method validation parameters, such as accuracy, precision, robustness and ruggedness, and selectivity are also reported. The composition of CT complex was found to be 1:1. The proposed method was successfully applied to the determination of the active ingredient in commercial tablets; and the results were in good agreement with those obtained by the official method.

Item Type:	Article
Uncontrolled Keywords:	Levocetirizine, Spectrophotometry, Charge-transfer complex, Pharmaceuticals
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	24 Jul 2019 10:21
Last Modified:	24 Jul 2019 10:21
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5530

Actions (login required)

View Item