Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles – A new class of promising antimicrobials

Suhas, R. and Chandrashekar, S. and Channe Gowda, D. (2012) Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles – A new class of promising antimicrobials. European Journal of Medicinal Chemistry, 48. 179 - 191. ISSN 1768-3254

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Abstract

Forty five new derivatives of ureas and thioureas were synthesized by the reaction of peptide conjugated heterocycles with isocyanates and isothiocyanates respectively. All the compounds have been characterized by IR, 1H NMR, mass and elemental analysis. The compounds were evaluated for their ability to inhibit the growth of a panel of microorganisms and all the synthesized compounds displayed an excellent antimicrobial activity. From structure–activity relationship studies, it was apparent that thioureas infact is slightly more active than ureas. Also, substituents on the phenyl ring of the title compounds play a key role in the activity. Further, compound 40 is nearly twenty times more potent than the standard used. These results present a platform for the further studies in this line.

Item Type:	Article
Uncontrolled Keywords:	Synthesis, Derivatives of conjugates, Uriedo and thiouriedo, Potent antimicrobials
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	24 Jul 2019 05:32
Last Modified:	24 Jul 2019 05:32
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5494

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