Structure-based rationale design and synthesis of Aurantiamide Acetate Analogues – towards a new class of potent analgesic and Anti-inflammatory Agents

Suhas, R. and Channe Gowda, D. (2012) Structure-based rationale design and synthesis of Aurantiamide Acetate Analogues – towards a new class of potent analgesic and Anti-inflammatory Agents. Chemical Biology & Drug Design, 79 (5). pp. 850-862. ISSN 1747-0285

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Abstract

A series of new aurantiamide acetate analogues were synthesized by modifying its N-terminal substitution and the amino acid residue. The structure of all these compounds was established on the basis of analytical and spectral studies. All the new derivatives were evaluated in vivo for their analgesic activity by tail flick method in mice and anti-inflammatory activity against carrageenan-induced oedema in albino rats at different doses (25, 50 and 100 mg/kg body weight). All the compounds exhibited significant pharmacological activity with no ulcerogenic liability. In particular, pentapeptides and tricosamers (30 amino acids) containing analogues have demonstrated high potency than the reference standards. These compounds hold promise for further development.

Item Type:	Article
Uncontrolled Keywords:	analgesics, anti-inflammatory agents, aurantiamide acetate, elastin-based peptides, synthesis
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	22 Jul 2019 09:31
Last Modified:	22 Jul 2019 09:31
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5430

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