Rapid and sensitive extraction-free spectrophotometric methods for the determination of pheniramine maleate using three Sulphonthalein Dyes

Raghu, M. S. and Basavaiah, K. (2012) Rapid and sensitive extraction-free spectrophotometric methods for the determination of pheniramine maleate using three Sulphonthalein Dyes. Proceedings of the National Academy of Sciences, India Section A: Physical Sciences, 82 (3). pp. 187-196. ISSN 2250-1762

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Abstract

Three extraction- free spectrophotometric methods which are simple, selective and sensitive are described for the quantitation of pheniramine maleate (PAM), an anti allergic drug, in pure form and in its formulations. The methods are based on formation of yellow colored ion-pair complexes between PAM and three sulphonthalein dyes viz., bromothymol blue (method A), and bromocresol purple (method B) in dichloromethane, and bromocresol green (method C) in chloroform medium. The experimental variables such as reagent concentration, solvent medium and reaction time have been carefully optimized to achieve the highest sensitivity. Beer's law is obeyed over the concentration ranges 1.0--16.0 for method A and method B, and 0.6--12 μg ml−1 PAM for method C with correlation coefficient of 0.999 for method A and method B, and 0.997 for method C. The molar absorptivity values are calculated to be 2.3 × 104, 2.5 × 104 and 3.0 × 104 l mol−1 cm−1 for the methods in the same order. The composition of the ion-pairs was found to be 1:1 by Job's method of continuous variations and the conditional stability constant (Kf) of the complexes have been calculated. The proposed methods were applied successfully to the determination of PAM in tablets and injection with good accuracy and precision and without interferences from common additives. The results obtained by the proposed methods were compared favourably with those of the reference method.

Item Type:	Article
Uncontrolled Keywords:	Pheniramine maleate, Sulphonthalein dyes, Spectrophotometry, Ion-pair, Pharmaceuticals
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	17 Jul 2019 09:22
Last Modified:	17 Jul 2019 09:22
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5303

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