Synthesis of Some Novel 2-2-(aroyl-aroxy)-methyl-4-phenyl-1,3-thiazoles as potent anti-inflammatory agents

Rai, Neithnadka Premsai and Venu, T. D. and Manuprasad, B. K. and Sheena, S. and Arunachalam, P. N. and Aiysha Firdouse (2010) Synthesis of Some Novel 2-2-(aroyl-aroxy)-methyl-4-phenyl-1,3-thiazoles as potent anti-inflammatory agents. Chemical Biology & Drug Design, 75 (4). pp. 400-406. ISSN 1747-0285

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Abstract

A series of 2-2-(aroyl-aroxy)-methyl-4-phenyl-1,3-thiazoles 4a–j were obtained via multiple step synthesis sequence beginning with the hydroxybenzophenones (1a–g). Hydroxybenzophenones on reaction with chloroacetonitrile affords (2-benzoyl) phenoxy acetonitrile (2a–g), which reacts with H2S/NH4OH and yields (2-benzoyl) phenoxy acetothiamide (3a–g), which on treatment with phenacylbromides affords 2-2-(aroyl-aroxy)-methyl-4-phenyl-1,3-thiazoles (4a–j). All the newly synthesized compounds were evaluated for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, (4g), compounds with chloro substituents showed more potent activity than the standard drug phenyl butazone at all doses tested.

Item Type:	Article
Uncontrolled Keywords:	anti-inflammatory activity, benzophenones, 1,3-thiazoles
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	15 Jul 2019 07:11
Last Modified:	06 Dec 2022 09:09
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5186

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