Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues

Prashanth, M. K. and Revanasiddappa, H. D. and Rai, K. M. Lokanatha and Veeresh, B. (2012) Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. Bioorganic & Medicinal Chemistry Letters, 22 (23). 7065 - 7070. ISSN 1464-3405

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Abstract

A series of piperamide derivatives (8a–j) was synthesized with various substituted piperidine and piperazine compounds. The prepared compounds were evaluated for antibacterial activity against gram-positive and gram-negative bacteria and antifungal activity by disc diffusion method. The antioxidant activity of the compounds was evaluated by DPPH and superoxide radical scavenging method and antidepressant activity using forced swim and tail suspension behavioral despair tests in mice. The compounds 8a, 8b and 8c were investigated for their monoamine oxidase A and B (MAO-A and MAO-B) inhibitory property. Some of the test compounds were active in forced swim test (FST) and tail suspension test (TST). Compounds 8a and 8b showed a significant effect, when compared to standard drug, clorgyline.

Item Type:	Article
Uncontrolled Keywords:	Piperamides, Antidepressant, Antioxidant, MAO-A, MAO-B
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	12 Jul 2019 06:24
Last Modified:	13 Jan 2023 11:21
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5137

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