Sumitra Mangasuli, N. and Kallappa Hosamani, M. and Devarajegowda, H. C. and Kurjogi, Mahantesh M. and Joshi, Shrinivas D. (2018) Synthesis of coumarin-theophylline hybrids as a new class of anti-tubercular and anti-microbial agents. European Journal of Medicinal Chemistry, 146. 747 - 756. ISSN 1768-3254
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A series of novel coumarin-theophylline hybrids were synthesized and examined for their anti-tubercular activity in vitro against Mycobacterium tuberculosis H37Rv, anti-microbial activity in vitro against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacterias (Escherichia coli, Salmonella typhi) as well as fungi (Candida albicans). The compound (3a) has shown excellent anti-tubercular activity with MIC of 0.12 μg/mL. Electron donating compounds (3a, 3f) have displayed significant anti-microbial activity. The compounds have also been precisely elucidated using single crystal X-ray diffraction techniques. Molecular docking study has been performed against 4DQU enzyme of Mycobacterium tuberculosis showed good binding interactions and is in agreement with the in vitro results.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Coumarin-theophylline hybrids, Molecular docking, Anti-tuberculosis, Anti-microbial, X-ray structure |
| Subjects: | D Physical Science > Physics |
| Divisions: | Yuvaraj college > Physics |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 11 Jul 2019 11:18 |
| Last Modified: | 11 Jul 2019 11:18 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/5092 |
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