The role of reactive oxygen species and ferroptosis in heme-mediated activation of human platelets

Naveen Kumar, S. K. and Sharath Babu, B. N. and Hemshekhar, M. and Kemparaju, K. and Girish, K. S. and Mugesh, G. (2018) The role of reactive oxygen species and ferroptosis in heme-mediated activation of human platelets. ACS Chemical Biology, 13 (8). pp. 1996-2002. ISSN 1554-8937

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Abstract

Hemolysis, a process by which the destruction of red blood cells leads to the release of hemoglobin, is a critical event observed during hemolytic disorders. Under oxidative stress conditions, hemoglobin can release its heme prosthetic group, which is highly cytotoxic and can catalyze the generation of reactive oxygen species (ROS), leading to several undesired redox reactions in the cells. Herein, we demonstrate for the first time that heme can mediate the activation and death of human platelets through ferroptosis, which is an iron-dependent form of nonapoptotic cell death. This study also suggests that the heme-mediated lipid peroxidation and ferroptosis in platelets may play an important role in hemolytic disorders.

Item Type:	Article
Additional Information:	PMID: 29869870
Subjects:	C Chemical Science > Biochemistry
Divisions:	Department of > Biochemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	08 Jul 2019 06:45
Last Modified:	19 Dec 2020 05:10
URI:	http://eprints.uni-mysore.ac.in/id/eprint/4869

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