Synthesis, characterization, and in vitro antimicrobial evaluation of new 5-chloro-8-bromo-3-aryl-1,2,4-triazolo4,3-cpyrimidines

Prasanna Kumar, B. N. and Mohana, K. N. and Mallesha, L. (2014) Synthesis, characterization, and in vitro antimicrobial evaluation of new 5-chloro-8-bromo-3-aryl-1,2,4-triazolo4,3-cpyrimidines. Medicinal Chemistry Research, 23 (1). pp. 445-453.

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Abstract

A series of new 5-chloro-8-bromo-3-aryl-1,2,4-triazolo4,3-cpyrimidines (4a-j) have been accomplished in excellent yields by the oxidative cyclization of pyrimidinylhydrazines (3a-j) of various aryl aldehydes with one equivalents of iodobenzene diacetate in methanol. The chemical structures of the synthesized compounds were confirmed by elemental analyses, FT-IR, 1H NMR, 13C NMR, and mass spectral studies. Ten new compounds (4a-j) were tested in vitro for their antimicrobial activity against clinically isolated strains. Variable and modest activities were observed against the investigated strains of bacteria and fungi. Compounds 4f, 4i, and 4j demonstrated good antimicrobial activity against all the tested microbial strains.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	14 Jul 2019 09:21
Last Modified:	30 Jun 2020 10:14
URI:	http://eprints.uni-mysore.ac.in/id/eprint/4453

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